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I have code to get picture from web cam to picturebox. But this code relays on picturebox's handle, if i minimize the program, it doesn't work (my motion detection). How could i get picture from web cam directly to bitmap variable ? and then use the bitmap with my needs ?

you could resize the form to a little window in the upper right cornor? so it is not completly minimized

I tried that, also its topmost, i even tried to find a handle for a game so that webcam can capture frames there, but nothing. I want this to get picture while in game.

You should probaly look into how fraps and wegame and such is working then

Bumping because I would like to know this too, and the topic is still open.

You can set the form opacity to 0%

If you are using a capture window to access the webcam then you can use the PrintWindow function to retrieve the image.